Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.
Identifieur interne : 002137 ( Main/Exploration ); précédent : 002136; suivant : 002138Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.
Auteurs : M L Clements [États-Unis] ; S D Sears ; K. Christina ; B R Murphy ; M H SnyderSource :
- Journal of clinical microbiology [ 0095-1137 ] ; 1989.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Grippe humaine (), Gènes viraux, Humains, Relation dose-réponse (immunologie), Réplication virale, Sous-type H3N2 du virus de la grippe A, Test ELISA, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Vaccins atténués (effets indésirables), Vaccins atténués (immunologie), Vaccins synthétiques (effets indésirables), Vaccins synthétiques (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (physiologie), Électrophorèse sur gel de polyacrylamide.
- MESH :
- biosynthèse : Anticorps antiviraux.
- effets indésirables : Vaccins antigrippaux, Vaccins atténués, Vaccins synthétiques.
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Vaccins atténués, Vaccins synthétiques, Virus de la grippe A.
- physiologie : Virus de la grippe A.
- Animaux, Grippe humaine, Gènes viraux, Humains, Relation dose-réponse (immunologie), Réplication virale, Sous-type H3N2 du virus de la grippe A, Test ELISA, Tests d'inhibition de l'hémagglutination, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (biosynthesis), Dose-Response Relationship, Immunologic, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Genes, Viral, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (physiology), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Vaccines, Attenuated (adverse effects), Vaccines, Attenuated (immunology), Vaccines, Synthetic (adverse effects), Vaccines, Synthetic (immunology), Virus Replication.
- MESH :
- chemical , adverse effects : Influenza Vaccines, Vaccines, Attenuated, Vaccines, Synthetic.
- chemical , biosynthesis : Antibodies, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Synthetic.
- physiology : Influenza A virus.
- prevention & control : Influenza, Human.
- Animals, Dose-Response Relationship, Immunologic, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Genes, Viral, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H3N2 Subtype, Virus Replication.
Abstract
We compared the abilities of the six internal RNA segments of two avian influenza viruses, A/Mallard/Alberta/88/76 (H3N8) and A/Mallard/NY/6750/78 (H2N2), to confer attenuation on wild-type human influenza A/Bethesda/1/85 (H3N2) virus in seronegative adult volunteers. Live avian-human influenza A reassortant virus vaccines derived from either avian virus parent were comparable in the following properties: safety, infectivity, immunogenicity, and genetic stability. Since the avian influenza A/Mallard/Alberta/76 virus offered no clear advantage as a donor virus, we will conduct our future evaluations on live influenza A virus reassortants derived from the more extensively characterized avian influenza A/Mallard/NY/78 virus.
PubMed: 2913033
Affiliations:
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Le document en format XML
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Live avian-human influenza A reassortant virus vaccines derived from either avian virus parent were comparable in the following properties: safety, infectivity, immunogenicity, and genetic stability. Since the avian influenza A/Mallard/Alberta/76 virus offered no clear advantage as a donor virus, we will conduct our future evaluations on live influenza A virus reassortants derived from the more extensively characterized avian influenza A/Mallard/NY/78 virus.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Christina, K" sort="Christina, K" uniqKey="Christina K" first="K" last="Christina">K. Christina</name><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name><name sortKey="Sears, S D" sort="Sears, S D" uniqKey="Sears S" first="S D" last="Sears">S D Sears</name><name sortKey="Snyder, M H" sort="Snyder, M H" uniqKey="Snyder M" first="M H" last="Snyder">M H Snyder</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Clements, M L" sort="Clements, M L" uniqKey="Clements M" first="M L" last="Clements">M L Clements</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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